Saturday, August 8, 2015

Castrate Resistant Prostrate Cancer - 2013 Perspective by Professor Gavin Marx

The Pca Continuum Chart

There have been tremendous research made and successes achieved in treatments for prostrate cancer in the past 10 years, particularly prostrate cancer in its advanced stage and castrate restistent. The Prostrate Cancer Foundation of Australia and Professor Gavin Marx from the Sydney Adventist Hospital, Australia published a talk and discussion in U-tube on 16 October 2013.

Some important points to note from the talk are:

Prostrate Cancer is now identified and seen as a heterogeneous disease. Each prostrate cancer patient will definitely respond differently from another patient. Hence individualised treatments are based on the patient.

The use of Taxotere can reduce the risk of death by 24%, the median of survivorship is incereased to 18.9 months and 30% patients treated with Taxotere survived two years more than the previous Mitoxantrone.

Emerging therapies are seen in chemotherapy, targeted therapies and immunotherapy and timming and sequencing the modality is a better option than combination modality. Combinations modalities with biologics are now researched into with clinical trials. Second and Third line therapy is now available. eg. Cabozantonib.

And the best news of all is that newer drugs are now better tolerated.

Listen to the very informative and excellent talk here:

Take care

Allen Lai

Friday, August 7, 2015

Immunotherapy for Prostrate Cancer, present availability and on going trials

Systemic Immunotherapy treatment for cancer looks promising and is currently the most preferred treatments since 2010. And prostrate cancer seems to be in the forefront with approved drugs by the FDA. Today there are several immune based cancer treatments available, albeit extending survivability by seven or so months. Currently there are three approaches in Immunotherapy for prostrate cancer. Therapeutic cancer vaccines, Checkpoint inhibitors/immune modulators and Adoptive T cell therapies.

Hopefully more trials will come to its end periods with successful results sooner than later. Let us continue to keep fit and healthy , until full fledged immunotherapies are readily available.

Read the latest report on Immunotherapies for prostrate cancer as at September 2014 here:

Take care

Allen Lai

Monday, August 3, 2015

The Emperor of all Maladies

This classic Pulitzer Prize winner book in 2011 is now a sensation on TV production with US prime time PBS TV. The documentary film produced by Ken Burns is scheduled to be viewed over 3 two hours series. The book The Emperor of all Maladies is written by Dr Siddhartha Mukherjee MD, PHD.  Dr Mukherjee is a professor of medicine in Columbia University, USA.

The film is very interesting and worth every minute watching it. It describes the historical biography of cancer, its past and its future. It describes the battles with cancer fought won and lost. And most important of all it describes the fight is now a teamwork with you and your Oncologist fighting back to back to fend off cancer. A fight that can be won with your personal efforts, determination and true grit.

View the first instalment of the TV series on U-tube here :

You will definitely feel better and have a better of understanding of cancer after watching it. Read the book if you have the time.

Take care.

Allen Lai