Wednesday, June 28, 2017

Further therapies




As our line of defenses in treatments fail, PCa advances into a new state of growth. This is generally known as advanced PCa. Advanced PCa is known to be in any one of these state:
Metastatic, asymptomatic, hormone-refractory prostate cancer.
Metastatic castrate-resistant (mCRPC).
Androgen-independent (AI) prostate cancer.
Our Oncologist will have to determine the state of our advanced PCa in order to prescribe the next line of defense. Drugs and protocols for advanced PCa are actively on-going. Immunotherapy leads in this area of treatment.
Cancer patients need to know that Radiotherapy can be done after Prostatectomy, but Prostatectomy cannot be done after Radiotherapy. How ever Hormone Therapy is the standard treatment protocol after either treatment fails.
The following FDA approved drugs may be prescribed in addition to hormone therapy:
Abiraterone (Zytiga) and prednisone.
Enzalutamide (Xtandi).
Radium-223 (Xofigo) for men with cancer that has spread to the bone.
Docetaxel (Docefrez, Taxotere) and prednisone.
Sipuleucel-T (Provenge) for men who have few or no symptoms from the cancer
Cabazitaxel (Jevtana) and prednisone for men with prostate cancer that has worsened while receiving docetaxel.
Mitoxantrone (Novantrone) plus prednisone.
Bicalutamide (Casodex), flutamide (Eulexin), nilutamide (Nilandron), which are all types of anti-androgens.
Ketoconazole (Nizoral, Xolegel).
Low-dose corticosteroids.

Take care

Allen Lai













Blocking Angiogenesis





Angiogenesis is the body’s process of creating new blood vessels, generally controlled by some chemicals in our bodies. At the same time our body can also generate angiogenesis inhibitors to interfere with blood vessel formation. Cancer cells rely on angiogenesis to grow, that’s where it draws its blood together with its supply of oxygen and nutrients to grow and spread.

The following are known to have natural angiogenesis inhibitors properties or as anti-angiogenesis food:
Red wine,
Turmeric.
Berries.
Tomato.
Lemon.
Dark Chocolate.
Green tea.

There many types of drugs that block blood vessel growth, namely drugs that block the vascular endothelial growth factor(VEGF) from attaching itself to the receptors on the cells lining the blood vessel to drugs that block signaling within the cell. Drugs like Avastin are used block VEGF and Sunitinib is used to block signals inside the cell.
There are also drugs that interfere signals between cells. These type of drugs include Revlimid.

There is so far only one anti angiogenesis treatment for PCa. The FDA has approved Provenge (Sipuleucel-T) to be used for advanced PCa. However Provenge is only approved for asymptomatic metastasis PCa.

Hopefully FDA will approve more drugs for advanced PCa in the near future as there are many on -going clinical trials at its ending phase.

Take care

Allen Lai




Saturday, June 17, 2017

UMMC EXERCISE SUPPORT GROUP -ESG









The ESG was founded in 2014 at the University Malaya Medical Centre. The Support Group provide full gym works and active fun activities for all types of cancer survivors. Sessions are organised every Saturday morning at the UMMC under the supervision of the Sports medicine Department. Faculty staff will be at hand to assist and monitor all sessions. Fun activities include Zumba dances, runs, excursions and trekking. The ESG caters to all cancer survivors.

Below is the link to the UMMC ESG.

https://www.facebook.com/pg/exercisesupportgroup/about/?ref=page_internal


Take care, have fun and enjoy.

Allen Lai

Prostate Cancer and Exercise







I cannot over emphasise the importance of exercise for PCa, or for that matter exercise for all types of cancers.
Most cancer treatment centres today prescribe exercise as a form of therapy. Exercises does wonders to the body, no matter how old you are or how frail you are. I thank my belief that exercising is the least I can do for myself. Exercising over the years have paid off. It has helped me to cope with the harsh treatments and also calm myself when I start to worry. Now I have combined exercise with a passion to photograph birds. Yes a dual therapy. Birding has taught me to be patient and calm as I stalk near to photograph the bird. I can be very focused when I go birding. Of course the exercise part is actually carrying the heavy load of the camera gears and tripods and tracking long distances into the bird's habitats.

Below is a link to The Institute For Prostrate Cancer Research's video on PCa and Exercising. Read it  for better assurance.


https://www.youtube.com/watch?time_continue=2&v=YAgUtHNt530


Take care

Allen Lai

Friday, June 16, 2017

Systemic Therapies for Metastatic Pca cancer






Most of are out of the woods after our initial primary treatments which has an almost "8 years remission  period". We just monitor our PSA on a scheduled programme as prescribed by our Oncologist. The 8 years honeymoon period is a given, to all who had done the primary treatments after scanning positive. Yes eventually there will  be a rise in the PSA, some faster than others. And rise it will until we reach the next PCa biomarker, when our Oncologist will propose the next round of treatments. Systemic therapies are the buzz words today. All is not lost, just another round of treatments with new drugs and with better efficacies, precision and focus.

View MSKCC's available systemic therapies below


https://www.mskcc.org/cancer-care/types/prostate/treatment/systemic-therapies

Take care

Allen Lai


New Drugs approved by the FDA 2017








Yes I have not been posting articles and references for sometime now. How time has passed. And that is good because the FDA is approving more drugs for PCa. Here is the full list as at March 2017.
See link below.


https://www.cancer.gov/about-cancer/treatment/drugs/prostate



Take care

Allen Lai

Friday, June 9, 2017

PSA baseline 2017 is now 0.25








It has been a good year for me in 2016 with a total PSA rise from 0.162 to 0.250. The second half of 2016 rose by 0.06

Yesterday I visited IKN for my biannual checkup. My PSA reading was 0.260, only a 0.01 point rise. The first half of 2017 rose by only 0.01. A DROP of 0.05 points. It looks like my new PSA baseline is now 0.25.

Weight constant at 70 kg
BP good at 117/76
Pulse rate at 104 bpm
Body Oxygen level at 97%


I am good save for my blood sugar level. I even had an EGC done to confirm my heart beats and rhythm.

Take care


Allen Lai